rs10469074 - GALR1 - BDP1P

Magnitude 2.2 · 1 study on file

Reported associations

• Genome-wide association study of plasma levels of polychlorinated biphenyls disclose an association with the CYP2B6 gene in a population-based sample - Unknown journal (n.d.) · Unknown authors · PubMed 25839716

  ABSTRACT: Background Polychlorinated biphenyls (PCBs) are a group of man-made environmental pollutants which accumulate in humans with adverse health effects. To date, very little effort has been devoted to the study of the metabolism of PCBs on a genome-wide level. Objectives Here, we conducted a genome-wide association study (GWAS) to identify genomic regions involved in the metabolism of PCBs. Methods Plasma levels of 16 PCBs ascertained in a cohort of elderly individuals from Sweden (n=1016) were measured using gas chromatography-high resolution mass spectrophotometry (GC-HRMS). DNA samples were genotyped on the Infinium Omni Express bead microarray, and imputed up to reference panels from the 1000 Genomes Project. Association testing was performed in a linear regression framework un

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