Expressive

rs10468909 - ASXL3

Magnitude 2.2 · 1 study on file

Reported associations

  • Genome-wide meta-analysis of insomnia prioritizes genes associated with metabolic and psychiatric pathways. - Nature genetics (2022) · Watanabe K, Jansen PR, Savage JE, Nandakumar P, Wang X, Hinds DA, Gelernter J, Levey DF, Polimanti R, Stein MB, Van Someren EJW, Smit AB, Posthuma D · PubMed 35835914

    Insomnia is a heritable, highly prevalent sleep disorder for which no sufficient treatment currently exists. Previous genome-wide association studies with up to 1.3 million subjects identified over 200 associated loci. This extreme polygenicity suggested that many more loci remain to be discovered. The current study almost doubled the sample size to 593,724 cases and 1,771,286 controls, thereby increasing statistical power, and identified 554 risk loci (including 364 novel loci). To capitalize on this large number of loci, we propose a novel strategy to prioritize genes using external biological resources and functional interactions between genes across risk loci. Of all 3,898 genes naively implicated from the risk loci, we prioritize 289 and find brain-tissue expression spec

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Discuss with your doctor

  • ASXL3 rs10468909 variant and insomnia risk with healthcare provider Moderate

    genetic predisposition warrants clinical evaluation to identify contributing factors and treatment options

    inform provider of genetic variant, provide sleep history, discuss screening for underlying sleep disorders

Lifestyle

  • consistent sleep schedule and optimized sleep environment Moderate

    ASXL3 rs10468909 associated with increased insomnia risk; sleep hygiene reduces symptom severity and onset latency

    maintain regular bedtime/wake time within 30 min daily, keep bedroom dark quiet cool, target 7-9 hours per night

Screening

  • periodic assessment of sleep quality and insomnia symptoms Moderate

    genetic variant increases insomnia susceptibility; early identification enables timely intervention

    screen annually for sleep onset difficulties, nighttime awakenings, and daytime functional impairment