rs10468481 - SENP3-EIF4A1, SENP3

Magnitude 2.2 · 1 study on file

Reported associations

• Genetic Susceptibility for Low Testosterone in Men and Its Implications in Biology and Screening: Data from the UK Biobank - Unknown journal (n.d.) · Unknown authors · PubMed 34337532

  ABSTRACT: Background Despite strong evidence of heritability, few studies have attempted to unveil the genetic underpinnings of testosterone levels. Objective To identify testosterone-associated loci in a large study and assess their biological and clinical implications. Design, setting, and participants The participants were men from the UK Biobank. A two-stage genome-wide association study (GWAS) was first used to identify/validate loci for low testosterone (LowT, <8 nmol/l) in 80% of men (N = 148 902). The cumulative effect of independent LowT risk loci was then evaluated in the remaining 20% of men. Outcome measurements and statistical analysis Associations of single nucleotide polymorphisms (SNPs) with LowT were tested using an additive model. Analyses of the expression quanti

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