rs10465961 - TDRD10
Magnitude 2.2 · 1 study on file
Reported associations
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Mapping the proteo-genomic convergence of human diseases - Unknown journal (n.d.) · Unknown authors · PubMed 34648354
ABSTRACT: Characterization of the genetic regulation of proteins is essential for understanding disease etiology and developing therapies. We identified 10,674 genetic associations for 3,892 plasma proteins to create a cis-anchored gene-protein-disease map of 1,859 connections that highlights strong cross-disease biological convergence. This proteo-genomic map provides a framework to 1) connect etiologically related diseases, 2) provide biological context for new or emerging disorders, and 3) integrate different biological domains to establish mechanisms for known gene-disease links. Our results identify proteo-genomic connections within and between diseases and establish the value of cis-protein variants for annotation of likely causal disease genes at GWAS loci, addressing a major barrie
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Bloodwork
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inflammatory markers Moderate
rs10465961-A associates with elevated IL-6 receptor expression; monitoring IL-6 and CRP levels provides functional assessment of inflammation status
Periodic testing of hs-CRP and IL-6 levels, e.g., annually or after lifestyle changes
Diet
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anti-inflammatory dietary pattern Moderate
rs10465961-A associates with elevated IL-6 receptor expression; dietary patterns low in inflammatory markers reduce IL-6 signaling
Emphasize Mediterranean or DASH diet; limit processed foods and refined carbohydrates
Exercise
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regular aerobic exercise Moderate
Aerobic exercise reduces circulating IL-6 levels; protective against inflammation risk from IL-6-raising variants
150 minutes moderate-intensity aerobic activity per week