Expressive

rs10462335 - MEF2C

Magnitude 2.2 · 3 studies on file

Reported associations

  • Genome-Wide Association Study Shows that Executive Functioning Is Influenced by GABAergic Processes and Is a Neurocognitive Genetic Correlate of Psychiatric Disorders - Unknown journal (n.d.) · Unknown authors · PubMed 36150907

    ABSTRACT: Background: Deficits in executive functions (EFs), cognitive processes that control goal-directed behaviors, are associated with psychopathology and neurological disorders. Little is known about the molecular bases of EF individual differences. Prior candidate gene studies have been underpowered in their search for dopaminergic processes involved in cognitive functioning, and existing EF genome-wide association studies (GWASs) used small sample sizes and/or focused on individual tasks that are imprecise measures of EF. Methods: We conducted a GWAS of a Common EF (cEF) factor score based on multiple tasks in the UK Biobank (N=427,037 European-descent individuals). Results: We found 129 independent genome-wide significant lead variants in 112 distinct loci and that cEF was associat

  • Evidence for specificity of polygenic contributions to attainment in English, maths and science during adolescence - Unknown journal (n.d.) · Unknown authors · PubMed 33594131

    ABSTRACT: How well one does at school is predictive of a wide range of important cognitive, socioeconomic, and health outcomes. The last few years have shown marked advancement in our understanding of the genetic contributions to, and correlations with, academic attainment. However, there exists a gap in our understanding of the specificity of genetic associations with performance in academic subjects during adolescence, a critical developmental period. To address this, the Avon Longitudinal Study of Parents and Children was used to conduct genome-wide association studies of standardised national English (N = 5983), maths (N = 6017) and science (N = 6089) tests. High SNP-based heritabilities (h2SNP) for all subjects were found (41-53%). Further, h2SNP for maths and science re

  • Genome-wide analysis identifies molecular systems and 149 genetic loci associated with income - Unknown journal (n.d.) · Unknown authors · PubMed 31844048

    ABSTRACT: Socioeconomic position (SEP) is a multi-dimensional construct reflecting (and influencing) multiple socio-cultural, physical, and environmental factors. In a sample of 286,301 participants from UK Biobank, we identify 30 (29 previously unreported) independent-loci associated with income. Using a method to meta-analyze data from genetically-correlated traits, we identify an additional 120 income-associated loci. These loci show clear evidence of functionality, with transcriptional differences identified across multiple cortical tissues, and links to GABAergic and serotonergic neurotransmission. By combining our genome wide association study on income with data from eQTL studies and chromatin interactions, 24 genes are prioritized for follow up, 18 of which were previously assoc

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