rs10460393 - RFTN2 - MARS2

Magnitude 2.2 · 1 study on file

Reported associations

• COVID-19 and systemic lupus erythematosus genetics: A balance between autoimmune disease risk and protection against infection - Unknown journal (n.d.) · Unknown authors · PubMed 36327221

  ABSTRACT: Genome wide association studies show there is a genetic component to severe COVID-19. We find evidence that the genome-wide genetic association signal with severe COVID-19 is correlated with that of systemic lupus erythematosus (SLE), having formally tested this using genetic correlation analysis by LD score regression. To identify the shared associated loci and gain insight into the shared genetic effects, using summary level data we performed meta-analyses, a local genetic correlation analysis and fine-mapping using stepwise regression and functional annotation. This identified multiple loci shared between the two traits, some of which exert opposing effects. The locus with most evidence of shared association is TYK2, a gene critical to the type I interferon pathway, where the

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