rs10459463 - LINC02320

Magnitude 2.2 · 1 study on file

Reported associations

• Genome-wide Association Study of Posttraumatic Stress Disorder (PTSD) Re-Experiencing Symptoms in >165,000 US Veterans - Unknown journal (n.d.) · Unknown authors · PubMed 31358989

  ABSTRACT: Posttraumatic stress disorder (PTSD) is a major problem among military veterans and civilians alike, yet its pathophysiology remains poorly understood. We used genomewide association study (GWAS) and bioinformatic analyses, including 146,660 European-Americans (EAs) and 19,983 African-Americans (AAs) in the US Million Veteran Program, to identify genetic risk factors relevant to Intrusive reexperiencing of trauma -- the most characteristic symptom cluster of PTSD. In EAs, 8 distinct significant regions were identified. Three regions had P<5×10−10 -- CAMKV; chromosome 17 closest to KANSL1 but within a large high-LD region that also includes CRHR1; and TCF4. Associations were enriched with respect to the transcriptomic profiles of striatal medium spiny neurons. No significant as

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