rs10458787 - MANCR

Magnitude 2.2 · 1 study on file

Reported associations

• Genome-wide association study of height and body mass index in Australian twin families - Unknown journal (n.d.) · Unknown authors · PubMed 20397748

  ABSTRACT: Human height and body mass index are influenced by a large number of genes, each with small effects, along with environment. To identify common genetic variants associated with these traits, we performed genome-wide association studies in 11,536 individuals composed of Australian twins, family members, and unrelated individuals at ~550,000 genotyped SNPs. We identified a single genome-wide significant variant for height (P value = 1.06 × 10-9) located in HHIP, a well-replicated height-associated gene. Suggestive levels of association were found for other known genes associated with height (P values < 1 × 10-6): ADAMTSL3, EFEMP1, GPR126, and HMGA2; and BMI (P values < 1 × 10-4): FTO and MC4R. Together, these variants explain less than 2% of total phenotypic variation for height

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