rs10457220 - CDK19

Magnitude 2.2 · 1 study on file

Reported associations

• Common and Rare Variants Genetic Association Analysis of Circulating Neutrophil Extracellular Traps - Unknown journal (n.d.) · Unknown authors · PubMed 33717105

  ABSTRACT: Introduction Neutrophils contribute to host defense through different mechanisms, including the formation of neutrophil extracellular traps (NETs). The genetic background and underlying mechanisms contributing to NET formation remain unclear. Materials and Methods We performed a genome-wide association study (GWAS) and exome-sequencing analysis to identify common and rare genetic variants associated with plasma myeloperoxidase (MPO)-DNA complex levels, a biomarker for NETs, in the population-based Rotterdam Study cohort. GWAS was performed using haplotype reference consortium(HRC)-imputed genotypes of common variants in 3,514 individuals from the first and 2,076 individuals from the second cohort of the Rotterdam Study. We additionally performed exome-sequencing analysis in 960 i

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