rs10456561 - PHACTR1
Magnitude 2.2 · 1 study on file
Reported associations
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Multi-ancestry genome-wide study identifies effector genes and druggable pathways for coronary artery calcification - Unknown journal (n.d.) · Unknown authors · PubMed 37770635
ABSTRACT: Coronary artery calcification (CAC), a measure of subclinical atherosclerosis, predicts future symptomatic coronary artery disease (CAD). Identifying genetic risk factors for CAC may point to new therapeutic avenues for prevention. Currently, there are only 4 known risk loci for CAC identified from genome-wide association studies (GWAS) in the general population. Here, we conducted the largest multi-ancestry GWAS meta-analysis of CAC to date, which comprised 26,909 individuals of European ancestry and 8,867 individuals of African ancestry. We identified 11 independent risk loci, of which 8 are novel for CAC and 5 have not been reported for CAD. These novel CAC loci are related to bone mineralization, phosphate catabolism, and hormone metabolic pathways. Several novel loci harbor
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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Screening for coronary artery disease given genetic risk Moderate
Carriers of the A allele at rs10456561 show increased coronary artery calcification in GWAS analysis.
Discuss with cardiologist whether CAC screening is appropriate given genotype and risk factors