rs10455657 - LINC02549

Magnitude 2.2 · 1 study on file

Reported associations

• The genetic etiology of cannabis use initiation: a meta-analysis of genome-wide association studies and a SNP-based heritability estimation - Unknown journal (n.d.) · Unknown authors · PubMed 22823124

  ABSTRACT: While initiation of cannabis use is around 40% heritable, not much is known about the underlying genetic etiology. Here, we meta-analysed two genome-wide association studies of initiation of cannabis use with (>10,000 individuals). None of the genetic variants reached genome-wide significance. We also performed a gene-based association test, which also revealed no significant effects of individual genes. Finally, we estimated that only approximately 6.0% of the variation in cannabis initiation is due to common genetic variants. Future genetic studies using larger sample sizes and different methodologies (including sequencing) might provide more insight in the complex genetic etiology of cannabis use. FULL TEXT: [INTRO] Cannabis is the most widely used illicit drug worldwide, and

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