rs10447419 - SAMD3

Magnitude 4.5 · 1 study on file

Reported associations

• Generalization of Variants Identified by Genome-wide Association Studies for Electrocardiographic Traits in African Americans - Unknown journal (n.d.) · Unknown authors · PubMed 23534349

  ABSTRACT: SUMMARY Electrocardiographic (ECG) measurements vary by ancestry. Genome-wide association studies (GWAS) have identified loci that contribute to ECG measurements; however most are performed in Europeans collected from population-based cohorts or surveys. The strongest associations reported are in NOS1AP with QT interval and SCN10A with PR and QRS durations. The extent to which these associations can be generalized to African Americans has yet to be determined. Using electronic medical records, PR and QT intervals, QRS duration, and heart rate were determined in 455 African Americans as part of the Vanderbilt Genome-Electronic Records Project and Northwestern University NUgene Project. We tested for an association between these ECG traits and >930K SNPs. We identified a total 36 n

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