rs10447248 - FBXL17 - LINC01023

Magnitude 2.0 · 1 study on file

Reported associations

• Novel Locus FER Is Associated With Serum HMW Adiponectin Levels - Diabetes (2011) · Qi L, Menzaghi C, Salvemini L, De Bonis C, Trischitta V, Hu FB · PubMed 21700879

  ABSTRACT: OBJECTIVE High molecular weight (HMW) adiponectin is a predominant isoform of circulating adiponectin and has been related to type 2 diabetes. Previous linkage studies suggest that different genetic components might be involved in determining HMW and total adiponectin levels. RESEARCH DESIGN AND METHODS We performed a genome-wide association study (GWAS) of serum HMW adiponectin levels in individuals of European ancestry drawn from the Nurses' Health Study (NHS) (N = 1,591). The single nucleotide polymorphisms (SNPs) identified in the GWAS analysis were replicated in an independent cohort of Europeans (N = 626). We examined the associations of the identified variations with diabetes risk and metabolic syndrome. RESULTS We identified a novel locus near the FER gene (5q21) at a g

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