rs10447131 - LINC02241 - GUSBP1

Magnitude 2.2 · 1 study on file

Reported associations

• Genetic association of a gain of function interferon gamma receptor 1 (IFNGR1) polymorphism and the intergenic region LNCAROD/DKK1 with Behçet's disease - Unknown journal (n.d.) · Unknown authors · PubMed 33393726

  ABSTRACT: Objective: Behçet's disease is a complex systemic inflammatory vasculitis of incompletely understood etiology. We performed a large genetic study in Behçet's disease in a diverse multi-ethnic population. Methods: A total of 9,444 patients and controls from seven different populations were included in this study. Genotyping was performed using the Infinium ImmunoArray-24 V.1.0 or V.2.0 BeadChip. Analysis of expression data from stimulated monocytes, and epigenetic and chromatin interaction analyses were performed. Results: We identified two novel genetic susceptibility loci for Behçet's disease, including a risk locus in IFNGR1 (rs4896243, p value= 2.42 × 10−9; OR=1.25) and within the intergenic region LNCAROD/DKK1 (rs1660760, p value= 2.75 × 10−8; OR= 0.78). The ri

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