Expressive

rs1044690 - TMEM151B

Magnitude 2.8 · 2 studies on file

Reported associations

  • Genetic architecture of the inflammatory bowel diseases across East Asian and European ancestries - Unknown journal (n.d.) · Unknown authors · PubMed 37156999

    ABSTRACT: Inflammatory bowel diseases (IBD) are chronic disorders of the gastrointestinal tract with two subtypes: Crohn's disease (CD) and ulcerative colitis (UC). To date, most IBD genetic associations were derived from individuals of European ancestries (EUR). Here we report the largest IBD study of individuals of East Asian ancestries (EAS), including 14,393 cases and 15,456 controls. We found 80 IBD loci in EAS alone and 320 when meta-analyzed with ~370,000 EUR individuals (~30,000 cases), among which 81 are novel. EAS enriched coding variants implicate many new IBD genes, including ADAP1 and GIT2. While IBD genetic effects are generally consistent across ancestries, genetics underlying CD appears more ancestry dependent than UC, driven by both allele frequency (NOD2) and effect (TN

  • Genome-wide association study in a Korean population identifies six novel susceptibility loci for rheumatoid arthritis - Unknown journal (n.d.) · Unknown authors · PubMed 32723749

    ABSTRACT: Objective Genome-wide association studies (GWAS) in rheumatoid arthritis (RA) have discovered over 100 RA loci, explaining patient-relevant RA pathogenesis but showing a large fraction of missing heritability. As a continuous effort, we conducted GWAS in a large Korean RA case-control population. Methods We newly generated genome-wide variant data in two independent Korean cohorts comprising 4068 RA cases and 36 487 controls, followed by a whole-genome imputation and a meta-analysis of the disease association results in the two cohorts. By integrating publicly available omics data with the GWAS results, a series of bioinformatic analyses were conducted to prioritise the RA-risk genes in RA loci and to dissect biological mechanisms underlying disease associations. Results We i

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Diet

  • Anti-inflammatory dietary pattern Moderate

    RA develops through immune activation in spleen and gut tissue; anti-inflammatory diet modulates intestinal and systemic immunity

    Mediterranean pattern: olive oil, fatty fish, vegetables, legumes, whole grains, limit processed foods

Discuss with your doctor

  • Discuss RA genetic risk with rheumatologist High

    Carrier status elevates RA susceptibility; proactive monitoring enables early intervention

Exercise

  • Regular aerobic and resistance activity Moderate

    Variant activates immune pathways in multiple tissues; exercise modulates immune function and reduces inflammatory markers

    150 minutes moderate aerobic activity plus 2 days resistance training weekly

Lifestyle

  • Smoking and air pollution exposure Moderate

    Study identifies lung as early RA inflammation site in interaction with smoking; variant affects respiratory immune response

Screening

  • Baseline rheumatoid arthritis laboratory testing High

    rs1044690 increases RA odds 1.2-fold via NFKBIE pathway; baseline markers enable early detection

    Anti-CCP antibody, rheumatoid factor, CRP, ESR; repeat annually if negative

  • Monitor for gastrointestinal symptoms Moderate

    rs1044690 associated with Crohn's disease; variant affects immune function in small intestine tissue

    Track chronic diarrhea, abdominal pain, weight loss, blood in stool; report to gastroenterologist if present