rs1043101 - SLC1A2, SLC1A2-AS1

Magnitude 2.8 · 1 study on file

Reported associations

• Genome-wide association studies of autoimmune vitiligo identify 23 new risk loci and highlight key pathways and regulatory variants - Unknown journal (n.d.) · Unknown authors · PubMed 27723757

  ABSTRACT: Vitiligo is an autoimmune disease in which depigmented skin results from destruction of melanocytes, with epidemiologic association with other autoimmune diseases. In previous linkage and genome-wide association studies (GWAS1, GWAS2), we identified 27 vitiligo susceptibility loci in patients of European (EUR) ancestry. We carried out a third GWAS (GWAS3) in EUR subjects, with augmented GWAS1 and GWAS2 controls, genome-wide imputation, and meta-analysis of all three GWAS, followed by an independent replication. The combined analyses, with 4,680 cases and 39,586 controls, identified 23 new loci and 7 suggestive loci, most encoding immune and apoptotic regulators, some also associated with other autoimmune diseases, as well as several melanocyte regulators. Bioinformatic analyses i

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