rs10429558 - FAM120A - PHF2

Magnitude 4.5 · 1 study on file

Reported associations

• Association analysis in over 329,000 individuals identifies 116 independent variants influencing neuroticism. - Nature genetics (2019) · Luciano M, Hagenaars SP, Davies G, Hill WD, Clarke TK, Shirali M, Harris SE, Marioni RE, Liewald DC, Fawns-Ritchie C, Adams MJ, Howard DM, Lewis CM, Gale CR, McIntosh AM, Deary IJ · PubMed 29255261

  Neuroticism is a relatively stable personality trait characterized by negative emotionality (for example, worry and guilt) ; heritability estimated from twin studies ranges from 30 to 50% , and SNP-based heritability ranges from 6 to 15% . Increased neuroticism is associated with poorer mental and physical health , translating to high economic burden . Genome-wide association studies (GWAS) of neuroticism have identified up to 11 associated genetic loci . Here we report 116 significant independent loci from a GWAS of neuroticism in 329,821 UK Biobank participants; 15 of these loci replicated at P < 0.00045 in an unrelated cohort (N = 122,867). Genetic signals were enriched in neuronal genesis and differentiation pathways, and substantial genetic correlations were found between neur

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