rs10428206 - CNTN3
Magnitude 4.5 · 1 study on file
Reported associations
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Genetic Variants in the Bone Morphogenic Protein Gene Family Modify the Association between Residential Exposure to Traffic and Peripheral Arterial Disease - Unknown journal (n.d.) · Unknown authors · PubMed 27082954
ABSTRACT: There is a growing literature indicating that genetic variants modify many of the associations between environmental exposures and clinical outcomes, potentially by increasing susceptibility to these exposures. However, genome-scale investigations of these interactions have been rarely performed particularly in the case of air pollution exposures. We performed race-stratified genome-wide gene-environment interaction association studies on European-American (EA, N = 1623) and African-American (AA, N = 554) cohorts to investigate the joint influence of common single nucleotide polymorphisms (SNPs) and residential exposure to traffic ("traffic exposure")-a recognized vascular disease risk factor-on peripheral arterial disease (PAD). Traffic exposure was estimated via the dis
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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personalized PAD risk assessment based on genetic variant Moderate
CNTN3 variant interaction with air pollution increases PAD risk; requires individualized assessment
Share this finding with your cardiologist for risk stratification and monitoring
Lifestyle
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prolonged exposure to traffic-related air pollution Moderate
CNTN3 rs10428206 variant increases PAD risk in presence of traffic air pollution
Choose lower-traffic routes, carpool, use public transit, or work remotely
Screening
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peripheral artery disease screening Moderate
Variant associated with increased PAD risk; earlier detection enables better management
Discuss timing and type with cardiologist or vascular medicine specialist