rs10427021 - INSR
Magnitude 2.2 · 1 study on file
Reported associations
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Genome-wide association analyses using electronic health records identify new loci influencing blood pressure variation - Unknown journal (n.d.) · Unknown authors · PubMed 27841878
ABSTRACT: Longitudinal electronic health records on 99,785 Genetic Epidemiology Research on Adult Health and Aging (GERA) cohort individuals provided 1,342,814 systolic and diastolic blood pressure measurements for a genome-wide association study on long-term average systolic, diastolic, and pulse pressure. We identified 39 novel among 75 significant loci (P≤5×10−8), most replicating in the combined International Consortium for Blood Pressure (ICBP, n=69,396) and UK Biobank (UKB, n=152,081) studies. Combining GERA with ICBP yielded 36 additional novel loci, most replicating in UKB. Combining all three studies (n=321,262) yielded 241 additional genome-wide significant loci, although for these no replication sample was available. All associated loci explained 2.9%/2.5%/3.1% of systolic/
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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hypertension risk assessment and monitoring plan Moderate
INSR rs10427021 contributes to blood pressure regulation through insulin signaling effects on vascular endothelial function
Lifestyle
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aerobic exercise and sodium restriction Moderate
Modifiable factors effectively lower blood pressure in genetically predisposed individuals
150 minutes moderate aerobic activity weekly; limit dietary sodium to 2300 mg daily
Screening
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blood pressure screening starting age 30 Moderate
INSR variants associated with diastolic blood pressure elevation warrant proactive cardiovascular screening
Annual blood pressure measurement; increase frequency if elevated