rs10424827 - FBXO27 - ACP7

Magnitude 2.2 · 1 study on file

Reported associations

• Investigating evidence for a causal association between inflammation and self-harm: A multivariable Mendelian Randomisation study - Unknown journal (n.d.) · Unknown authors · PubMed 32473944

  ABSTRACT: Highlights Observational studies of the role of inflammation on self-harm have conflicting results. We used Mendelian Randomisation, a novel causal inference technique to explore this. Genetic liability for high levels of IL-6 were not associated with self-harm. We found some evidence that higher levels of CRP were protective for self-harm. This potential protective effect of CRP has also been found for schizophrenia. Background The causal role of inflammatory markers on self-harm and suicidal risk has been studied using observational data, with conflicting results. Confounding and reverse causation can lead to bias, so we appraised question from a genetic perspective to protect against these biases. We measured associations between genetic liability for high levels of inflammato

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