Expressive

rs10424663 - APOC1 - APOC1P1

Magnitude 2.2 · 2 studies on file

Reported associations

  • Identification of 16 novel Alzheimer's disease loci using multi‐ancestry meta‐analyses - Unknown journal (n.d.) · Unknown authors · PubMed 39998322

    ABSTRACT: Abstract INTRODUCTION Alzheimer's disease (AD) is the most prevalent form of dementia. While many AD‐associated genetic determinants have been identified, few studies have analyzed individuals of non‐European ancestry. METHODS We conducted a multi‐ancestry genome‐wide association study (GWAS) of clinically diagnosed AD and AD‐by‐proxy using whole genome sequencing data from the National Institute on Aging Genetics of Alzheimer's Disease Data Storage Site (NIAGADS), National Institute of Mental Health, UK Biobank (UKB), and All of Us (AoU) consisting of 49,149 cases (12,074 clinically diagnosed and 37,075 AD‐by‐proxy) and 383,225 controls. Nearly half of NIAGADS and AoU participants were of non‐European ancestry. RESULTS For clinically diagnosed AD, we identified

  • Genetics of 35 blood and urine biomarkers in the UK Biobank - Unknown journal (n.d.) · Unknown authors · PubMed 33462484

    ABSTRACT: Clinical laboratory tests are a critical component of the continuum of care. We evaluate the genetic basis of 35 blood and urine laboratory measurements in the UK Biobank (n=363,228 individuals). We identify 1,857 loci associated with at least one trait, containing 3,374 fine-mapped associations, and additional sets of large-effect (> 0.1 sd) protein-altering, HLA, and copy-number variant associations. Through Mendelian Randomization analysis, we discover 51 causal relationships, including previously known agonistic effects of urate on gout and cystatin C on stroke. Finally, we develop polygenic risk scores for each biomarker and built 'multi-PRS' models for diseases using 35 PRSs simultaneously, which improved chronic kidney disease, type 2 diabetes, gout, and alcoholic cirr

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Bloodwork

  • Apolipoprotein B level screening Moderate

    SNP associates with elevated ApoB, a marker of cardiovascular risk

    Check ApoB as part of lipid panel, annually or per physician recommendation

Diet

  • Limit saturated fat intake Moderate

    High saturated fat intake elevates ApoB; limiting it supports cardiovascular health

    Reduce saturated fat to less than 7% of daily calories

  • Plant-based dietary pattern for ApoB reduction Moderate

    Dietary patterns rich in soluble fiber and plant sterols lower ApoB levels

    Emphasize whole grains, legumes, vegetables, nuts, and plant-based proteins

Exercise

  • Regular aerobic exercise Moderate

    Reduces ApoB levels and Alzheimer's disease risk

    150 minutes moderate-intensity aerobic exercise per week

Lifestyle

  • Cognitive stimulation and social engagement Moderate

    SNP associates with Alzheimer's disease risk; cognitive and social engagement reduce dementia risk

    Regular mentally challenging activities, maintain social connections, consider learning new skills

Screening

  • Cardiovascular risk assessment Moderate

    Elevated ApoB is associated with increased cardiovascular disease risk

  • Cognitive screening and neuropsychological assessment Moderate

    SNP associates with Alzheimer's disease risk; baseline cognitive assessment helps track changes

    Discuss appropriateness of baseline cognitive screening with doctor