rs10422253 - OPA3

Magnitude 2.8 · 1 study on file

Reported associations

• Genome-wide association of polygenic risk extremes for Alzheimer's disease in the UK Biobank - Unknown journal (n.d.) · Unknown authors · PubMed 35589863

  ABSTRACT: In just over a decade, advances in genome-wide association studies (GWAS) have offered an approach to stratify individuals based on genetic risk for disease. Using recent Alzheimer's disease (AD) GWAS results as the base data, we determined each individual's polygenic risk score (PRS) in the UK Biobank dataset. Using individuals within the extreme risk distribution, we performed a GWAS that is agnostic of AD phenotype and is instead based on known genetic risk for disease. To interpret the functions of the new risk factors, we conducted phenotype analyses, including a phenome-wide association study. We identified 246 loci surpassing the significance threshold of which 229 were not reported in the base AD GWAS. These include loci that showed suggestive levels of association in the

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