rs10421769 - GPATCH1

Magnitude 2.2 · 1 study on file

Reported associations

• Donor genetic variants as risk factors for thrombosis after liver transplantation: A genome‐wide association study - Unknown journal (n.d.) · Unknown authors · PubMed 33445220

  ABSTRACT: Thrombosis after liver transplantation substantially impairs graft‐ and patient survival. Inevitably, heritable disorders of coagulation originating in the donor liver are transmitted by transplantation. We hypothesized that genetic variants in donor thrombophilia genes are associated with increased risk of posttransplant thrombosis. We genotyped 775 donors for adult recipients and 310 donors for pediatric recipients transplanted between 1993 and 2018. We determined the association between known donor thrombophilia gene variants and recipient posttransplant thrombosis. In addition, we performed a genome‐wide association study (GWAS) and meta‐analyzed 1085 liver transplantations. In our donor cohort, known thrombosis risk loci were not associated with posttransplant thrombos

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