Expressive

rs1042121 - HLA-DPB1, HLA-DPA1

Magnitude 2.2 · 2 studies on file

Reported associations

  • Genome-wide meta-analysis in lichen sclerosus identifies 14 genomic risk loci. - The British journal of dermatology (2026) · Dand N, Rayinda T, Silz E, Thomas LF, Saklatvala JR, McSweeney SM, Ung CY, Christou E, Lewis F, Kettunen J, Huilaja L, Brumpton BM, Hveem K, Løset M, Tasanen K, McGrath JA, Simpson MA, Tziotzios C · PubMed 41850335

    Lichen sclerosus (LS) is a common and highly debilitating chronic inflammatory dermatosis that primarily affects genital skin in both females and males. Despite the utility of large genetic studies to reveal pathogenic mechanisms and suggest novel therapeutic targets, the genetic basis of LS remains largely unstudied. To identify genomic loci at which common genetic variation influences LS susceptibility and establish associated pathogenic mechanisms. Sex-stratified genome-wide association studies of genital LS were performed in three European biobanks (UK Biobank, the Trøndelag Health Study [HUNT] and FinnGen). LS cases were primarily identified via linked electronic health records from primary and/or secondary care. In total 6,681 female cases and 407,255 controls were included, with 97

  • Multi-ancestry genome-wide meta-analysis with 472,819 individuals identifies 32 novel risk loci for psoriasis - Unknown journal (n.d.) · Unknown authors · PubMed 39885523

    ABSTRACT: Background Psoriasis is a common chronic, recurrent, immune-mediated disease involved in the skin or joints or both. However, deeper insight into the genetic susceptibility of psoriasis is still unclear. Methods Here we performed the largest multi-ancestry meta-analysis of genome-wide association study including 28,869 psoriasis cases and 443,950 healthy controls. Results We identified 74 genome-wide significant loci for psoriasis. Of 74 loci, 32 were novel psoriasis risk loci. Across 74 loci, 801 likely causal genes are indicated and 164 causal genes are prioritized. SNP-based heritability analyses demonstrated that common variants explain 15% of genetic risk for psoriasis. Gene-set analyses and the genetic correlation revealed that psoriasis-related genes have the positive corr

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