Expressive

rs10420339 - PEPD

Magnitude 2.2 · 2 studies on file

Reported associations

  • Investigation of the impact of gynoid fat on steatotic and advanced liver diseases-Genomic and clinical perspectives from a large-scale population cohort. - Clinical nutrition (Edinburgh, Scotland) (2025) · Liu Z, Chen H, Du H, Lin G, Tu T, Wan Z, Zhao N, Li G, Tang B, Wu H, Bai X, Wang QL, Mi J · PubMed 41314110

    Gynoid fat (hip-thigh subcutaneous adiposity) is metabolically favorable, yet its genetic architecture and impact on liver diseases are unknown. We aimed to identify genetic determinants of gynoid tissue fat percentage (GTFP) and explore their clinical implications to liver disease. We conducted a genome-wide association study (GWAS) in 37,385 European individuals from the UK Biobank to identify genetic variants associated with GTFP. A polygenic risk score (PRS) was then derived for GTFP. Post-GWAS analyses, including colocalization, transcriptome-wide association studies (TWAS), logistic regression models, and interaction analyses, were employed to assess the impact of GTFP indicated by PRS on alcoholic and non-alcoholic fatty liver disease (NAFLD), metabolic dysfunction associated steato

  • Genetic analyses implicate complex links between adult testosterone levels and health and disease - Unknown journal (n.d.) · Unknown authors · PubMed 36653534

    ABSTRACT: Background Testosterone levels are linked with diverse characteristics of human health, yet, whether these associations reflect correlation or causation remains debated. Here, we provide a broad perspective on the role of genetically determined testosterone on complex diseases in both sexes. Methods Leveraging genetic and health registry data from the UK Biobank and FinnGen (total N = 625,650), we constructed polygenic scores (PGS) for total testosterone, sex-hormone binding globulin (SHBG) and free testosterone, associating these with 36 endpoints across different disease categories in the FinnGen. These analyses were combined with Mendelian Randomization (MR) and cross-sex PGS analyses to address causality. Results We show testosterone and SHBG levels are intricately tied t

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