rs10417097 - PBX4

Magnitude 2.0 · 1 study on file

Reported associations

• Investigation of parent-of-origin effects induced by fenofibrate treatment on triglycerides levels - BMC genetics (2019) · Sarnowski C, Lent S, Dupuis J · PubMed 30255771

  ABSTRACT: Background Genome-wide association studies performed on triglycerides (TGs) have not accounted for epigenetic mechanisms that may partially explain trait heritability. Results Parent-of-origin (POO) effect association analyses using an agnostic approach or a candidate approach were performed for pretreatment TG levels, posttreatment TG levels, and pre- and posttreatment TG-level differences in the real GAW20 family data set. We detected 22 genetic variants with suggestive POO effects with at least 1 phenotype (P ≤ 10− 5). We evaluated the association of these 22 significant genetic variants showing POO effects with close DNA methylation probes associated with TGs. A total of 18 DNA methylation probes located in the vicinity of the 22 SNPs were associated with at least 1

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