Expressive

rs10416125 - SLC44A2 - ILF3-DT

Magnitude 2.2 · 1 study on file

Reported associations

  • Translational genomics of osteoarthritis in 1,962,069 individuals - Unknown journal (n.d.) · Unknown authors · PubMed 40205036

    ABSTRACT: Osteoarthritis is the third most rapidly growing health condition associated with disability, after dementia and diabetes. By 2050, the total number of patients with osteoarthritis is estimated to reach 1 billion worldwide. As no disease-modifying treatments exist for osteoarthritis, a better understanding of disease aetiopathology is urgently needed. Here we perform a genome-wide association study meta-analyses across up to 489,975 cases and 1,472,094 controls, establishing 962 independent associations, 513 of which have not been previously reported. Using single-cell multiomics data, we identify signal enrichment in embryonic skeletal development pathways. We integrate orthogonal lines of evidence, including transcriptome, proteome and epigenome profiles of primary joint tiss

Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.

Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Discuss with your doctor

  • osteoarthritis prevention strategies Moderate

    Genetic testing reveals elevated osteoarthritis risk; collaborative discussion with healthcare provider enables personalized prevention plan.

    • GWAS_CATALOG:40205036

Exercise

  • regular low-impact aerobic exercise Moderate

    Regular aerobic activity maintains cartilage health and reduces joint stress; important countermeasure to elevated genetic osteoarthritis risk.

    150 minutes per week of moderate-intensity low-impact exercise such as swimming, cycling, or walking

    • GWAS_CATALOG:40205036

Lifestyle

  • maintain healthy body weight Moderate

    Excess weight increases mechanical load on joints; weight management reduces osteoarthritis incidence and progression in individuals with genetic susceptibility.

    Maintain BMI 18.5-24.9; if overweight, aim for 5-10 percent weight loss

    • GWAS_CATALOG:40205036

Screening

  • baseline joint health assessment Moderate

    Genetic variant strongly associated with osteoarthritis risk; baseline imaging enables detection of early pathology and guides prevention strategies.

    Obtain baseline joint imaging and clinical assessment; monitor annually or as clinically indicated

    • GWAS_CATALOG:40205036