rs10414623 - C3

Magnitude 2.2 · 1 study on file

Reported associations

• The correlates of neonatal complement component 3 and 4 protein concentrations with a focus on psychiatric and autoimmune disorders - Unknown journal (n.d.) · Unknown authors · PubMed 38116117

  ABSTRACT: Summary Complement components have been linked to schizophrenia and autoimmune disorders. We examined the association between neonatal circulating C3 and C4 protein concentrations in 68,768 neonates and the risk of six mental disorders. We completed genome-wide association studies (GWASs) for C3 and C4 and applied the summary statistics in Mendelian randomization and phenome-wide association studies related to mental and autoimmune disorders. The GWASs for C3 and C4 protein concentrations identified 15 and 36 independent loci, respectively. We found no associations between neonatal C3 and C4 concentrations and mental disorders in the total sample (both sexes combined); however, post-hoc analyses found that a higher C3 concentration was associated with a reduced risk of schizophre

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