Expressive

rs10411771 - BCL2L12

Magnitude 2.2 · 1 study on file

Reported associations

  • Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program - Unknown journal (n.d.) · Unknown authors · PubMed 39024449

    ABSTRACT: INTRODUCTION: Findings from genome-wide association studies (GWASs) have provided foundational knowledge of the genetic basis of disease, facilitating precision approaches for prevention and treatment. Current GWAS results are limited by underrepresentation of individuals from diverse populations, leading to concerns with generalizability regarding our knowledge of the relationships between genes, traits, and disease. The Department of Veterans Affairs (VA) Million Veteran Program (MVP), one of the largest US-based biobanks, addresses this need; 29% of MVP comprises individuals genetically similar to African (AFR), Admixed American (AMR), and East Asian (EAS) reference populations. With over 635,000 participants and more than 44.3M genotyped variants linked with detailed phenotyp

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Discuss with your doctor

  • personalized skin cancer risk management plan Moderate

    rs10411771-A confers 1.08x increased odds per allele for basal cell carcinoma

    review genetic risk status, optimal screening intervals, and prevention strategies with dermatologist

Lifestyle

  • enhanced sun protection and UV avoidance Moderate

    rs10411771-A increases BCC risk; PRRG2 eQTL in sun-exposed skin suggests cumulative pathway involvement

    daily SPF 30+ sunscreen, limit sun exposure 10am-4pm, wear protective clothing outdoors

Screening

  • skin cancer surveillance with dermatology Moderate

    rs10411771-A significantly increases basal cell carcinoma risk (p=9e-18); IRF3 modulation affects anti-tumor immunity

    annual full-body skin exam starting at age 30; sooner if fair skin or high sun exposure