rs10406410 - CATSPERD

Magnitude 2.2 · 1 study on file

Reported associations

• Genome-Wide Association Identifies the First Risk Loci for Psychosis in Alzheimer Disease - Unknown journal (n.d.) · Unknown authors · PubMed 34112972

  ABSTRACT: Psychotic symptoms, defined as the occurrence of delusions or hallucinations, are frequent in Alzheimer disease (AD with psychosis, AD+P). AD+P affects ~50% of individuals with AD, identifies a subgroup with poor outcomes, and is associated with a greater degree of cognitive impairment and depressive symptoms, compared to subjects without psychosis (AD−P). Although the estimated heritability of AD+P is 61%, genetic sources of risk are unknown. We report a genome-wide meta-analysis of 12,317 AD subjects, 5,445 AD+P. Results showed common genetic variation accounted for a significant portion of heritability. Two loci, one in ENPP6 (rs9994623, O.R. (95%CI) 1.16 (1.10, 1.22), p=1.26×10−8) and one spanning the 3'-UTR of an alternatively spliced transcript of SUMF1 (rs201109606,

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