Expressive

rs10405536 - SLC44A2 - ILF3-DT

Magnitude 2.2 · 1 study on file

Reported associations

  • Dyslipidaemia-Genotype Interactions with Nutrient Intake and Cerebro-Cardiovascular Disease - Unknown journal (n.d.) · Unknown authors · PubMed 35884923

    ABSTRACT: A comprehensive understanding of gene-diet interactions is necessary to establish proper dietary guidelines to prevent and manage cardio-cerebrovascular disease (CCD). We investigated the role of genetic variants associated with dyslipidaemia (DL) and their interactions with macro-nutrients for cardiovascular disease using a large-scale genome-wide association study of Korean adults. A total of 58,701 participants from a Korean genome and epidemiology study were included. Their dietary intake was assessed using a food frequency questionnaire. Dyslipidaemia was defined as total cholesterol (TCHL) ≥ 240 mg/dL, high-density lipoprotein (HDL) < 40 mg/dL, low-density lipoprotein (LDL) ≥ 160 mg/dL, triglycerides (TG) ≥ 200 mg/dL, or dyslipidaemia history. Their nutrient intake wa

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Diet

  • reduce dietary cholesterol intake Moderate

    Genetic predisposition to elevated cholesterol may be partially mitigated by reducing dietary cholesterol and saturated fat

    Limit red meat, full-fat dairy, and egg yolks; emphasize whole grains, fruits, and vegetables

Discuss with your doctor

  • cholesterol management strategy Moderate

    Genetic predisposition to elevated cholesterol warrants personalized cardiovascular risk assessment and management plan

    Discuss with healthcare provider whether genetic risk should influence cholesterol targets and treatment

Screening

  • cholesterol screening Moderate

    Rs10405536 G allele associated with elevated total cholesterol (~7% increase per copy, GWAS p=5e-7, n=58,701)

    Check total and HDL cholesterol annually, or more frequently if levels are elevated