rs10404384 - RN7SL150P - RPS4XP23
Magnitude 4.5 · 1 study on file
Reported associations
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Genome-wide analysis of disease progression in age-related macular degeneration. - Human molecular genetics (2019) · Yan Q, Ding Y, Liu Y, Sun T, Fritsche LG, Clemons T, Ratnapriya R, Klein ML, Cook RJ, Liu Y, Fan R, Wei L, Abecasis GR, Swaroop A, Chew EY, Weeks DE, Chen W · PubMed 29346644
Family- and population-based genetic studies have successfully identified multiple disease-susceptibility loci for Age-related macular degeneration (AMD), one of the first batch and most successful examples of genome-wide association study. However, most genetic studies to date have focused on case-control studies of late AMD (choroidal neovascularization or geographic atrophy). The genetic influences on disease progression are largely unexplored. We assembled unique resources to perform a genome-wide bivariate time-to-event analysis to test for association of time-to-late-AMD with ∼9 million variants on 2721 Caucasians from a large multi-center randomized clinical trial, the Age-Related Eye Disease Study. To our knowledge, this is the first genome-wide association study of disease progr
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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Discuss AMD management strategy with ophthalmologist Moderate
Genetic predisposition to faster AMD progression indicates need for proactive discussion of available management and prevention interventions.
Ask about AREDS supplementation, antioxidant intake, smoking cessation, and UV protection strategies.
Screening
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AMD progression monitoring via eye exams Moderate
Genetic variant is associated with significantly accelerated disease progression in age-related macular degeneration based on GWAS analysis.
Annual comprehensive eye exams by ophthalmologist; report vision changes promptly.