rs10404333 - RN7SL836P - GIPR
Magnitude 2.2 · 1 study on file
Reported associations
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Re-analysis of public genetic data reveals a rare X-chromosomal variant associated with type 2 diabetes - Unknown journal (n.d.) · Unknown authors · PubMed 29358691
ABSTRACT: The reanalysis of existing GWAS data represents a powerful and cost-effective opportunity to gain insights into the genetics of complex diseases. By reanalyzing publicly available type 2 diabetes (T2D) genome-wide association studies (GWAS) data for 70,127 subjects, we identify seven novel associated regions, five driven by common variants (LYPLAL1, NEUROG3, CAMKK2, ABO, and GIP genes), one by a low-frequency (EHMT2), and one driven by a rare variant in chromosome Xq23, rs146662075, associated with a twofold increased risk for T2D in males. rs146662075 is located within an active enhancer associated with the expression of Angiotensin II Receptor type 2 gene (AGTR2), a modulator of insulin sensitivity, and exhibits allelic specific activity in muscle cells. Beyond providing insi
Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.
Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Diet
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low glycemic index foods Moderate
Carriers with this variant show increased diabetes risk; low glycemic index foods improve glucose control and reduce diabetes progression.
Emphasize whole grains, legumes, non-starchy vegetables; limit refined carbohydrates
Exercise
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regular aerobic and resistance exercise Moderate
This variant increases diabetes risk through altered glucose homeostasis; exercise improves insulin sensitivity and glucose tolerance.
150 minutes moderate aerobic activity plus 2-3 days resistance training weekly
Screening
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type 2 diabetes screening Moderate
This variant increases type 2 diabetes risk by approximately 14.7%, warranting enhanced monitoring.
HbA1c or fasting glucose every 3 years; annually if overweight