rs10402457 - SPC24
Magnitude 2.2 · 1 study on file
Reported associations
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Genetics of 35 blood and urine biomarkers in the UK Biobank - Unknown journal (n.d.) · Unknown authors · PubMed 33462484
ABSTRACT: Clinical laboratory tests are a critical component of the continuum of care. We evaluate the genetic basis of 35 blood and urine laboratory measurements in the UK Biobank (n=363,228 individuals). We identify 1,857 loci associated with at least one trait, containing 3,374 fine-mapped associations, and additional sets of large-effect (> 0.1 sd) protein-altering, HLA, and copy-number variant associations. Through Mendelian Randomization analysis, we discover 51 causal relationships, including previously known agonistic effects of urate on gout and cystatin C on stroke. Finally, we develop polygenic risk scores for each biomarker and built 'multi-PRS' models for diseases using 35 PRSs simultaneously, which improved chronic kidney disease, type 2 diabetes, gout, and alcoholic cirr
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Diet
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Excess saturated fat intake Moderate
Saturated fat elevates LDL cholesterol; reduction is standard intervention for genetic cholesterol predisposition.
Limit saturated fat to 5-7% of daily calories
Discuss with your doctor
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Cholesterol management strategy Moderate
Genetic predisposition to elevated cholesterol warrants personalized discussion of screening intensity and preventive options.
Screening
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Lipid panel screening Moderate
SNP strongly associated with elevated LDL and total cholesterol (GWAS p=8.00e-45, n=355197)
Baseline lipid panel; annual monitoring if normal