rs10399952 - FMO1

Magnitude 4.5 · 1 study on file

Reported associations

• STXBP6 and B3GNT6 Genes are Associated With Selective IgA Deficiency - Unknown journal (n.d.) · Unknown authors · PubMed 34976003

  ABSTRACT: Immunoglobulin A Deficiency (IgAD) is a polygenic primary immune deficiency, with a strong genetic association to the human leukocyte antigen (HLA) region. Previous genome-wide association studies (GWAS) have identified five non-HLA risk loci (IFIH1, PVT1, ATG13-AMBRA1, AHI1 and CLEC16A). In this study, we investigated the genetic interactions between different HLA susceptibility haplotypes and non-MHC genes in IgAD. To do this, we stratified IgAD subjects and healthy controls based on HLA haplotypes (N = 10,993), and then performed GWAS to identify novel genetic regions contributing to IgAD susceptibility. After replicating previously published HLA risk haplotypes, we compared individuals carrying at least one HLA risk allele (HLA-B08:01-DRB103:01-DQB102:01 or HLA-DRB107:01-

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