rs1039716 - VDAC1P10 - KCTD3

Magnitude 2.2 · 1 study on file

Reported associations

• Biological Insights Into Muscular Strength: Genetic Findings in the UK Biobank - Unknown journal (n.d.) · Unknown authors · PubMed 29691431

  ABSTRACT: We performed a large genome-wide association study to discover genetic variation associated with muscular strength, and to evaluate shared genetic aetiology with and causal effects of muscular strength on several health indicators. In our discovery analysis of 223,315 individuals, we identified 101 loci associated with grip strength (P <5 × 10−8). Of these, 64 were associated (P < 0.01 and consistent direction) also in the replication dataset (N = 111,610). eQTL analyses highlighted several genes known to play a role in neuro-developmental disorders or brain function, and the results from meta-analysis showed a significant enrichment of gene expression of brain-related transcripts. Further, we observed inverse genetic correlations of grip strength with cardiometa

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