rs1034435 - TAFA5
Magnitude 2.2 · 1 study on file
Reported associations
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Two novel loci, COBL and SLC10A2, for Alzheimer's disease in African Americans - Unknown journal (n.d.) · Unknown authors · PubMed 27770636
ABSTRACT: Introduction African Americans' (AAs) late-onset Alzheimer's disease (LOAD) genetic risk profile is incompletely understood. Including clinical covariates in genetic analyses using informed conditioning might improve study power. Methods We conducted a genome-wide association study (GWAS) in AAs employing informed conditioning in 1825 LOAD cases and 3784 cognitively normal controls. We derived a posterior liability conditioned on age, sex, diabetes status, current smoking status, educational attainment, and affection status, with parameters informed by external prevalence information. We assessed association between the posterior liability and a genome-wide set of single-nucleotide polymorphisms (SNPs), controlling for APOE and ABCA7, identified previously in a LOAD GWAS of A
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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TAFA5 variant-associated Alzheimer's disease risk Low
rs1034435 A allele associates with increased late-onset Alzheimer's disease risk via effects on TAFA5 expression in critical brain regions
discuss genetic findings, familial risk, and early screening strategies with healthcare provider