Expressive

rs1032843 - RNU6-627P - FIGN

Magnitude 2.2 · 1 study on file

Reported associations

  • Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function - Unknown journal (n.d.) · Unknown authors · PubMed 26831199

    ABSTRACT: Reduced glomerular filtration rate defines chronic kidney disease and is associated with cardiovascular and all-cause mortality. We conducted a meta-analysis of genome-wide association studies for estimated glomerular filtration rate (eGFR), combining data across 133,413 individuals with replication in up to 42,166 individuals. We identify 24 new and confirm 29 previously identified loci. Of these 53 loci, 19 associate with eGFR among individuals with diabetes. Using bioinformatics, we show that identified genes at eGFR loci are enriched for expression in kidney tissues and in pathways relevant for kidney development and transmembrane transporter activity, kidney structure, and regulation of glucose metabolism. Chromatin state mapping and DNase I hypersensitivity analyses across

Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.

Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Diet

  • Sodium restriction to reduce blood pressure Moderate

    Dietary sodium reduction lowers blood pressure and proteinuria, key modifiable CKD risk factors

    Limit added salt and processed foods; target <2300 mg sodium daily

Discuss with your doctor

  • Genetic CKD risk and personalized screening strategy Moderate

    GWAS evidence warrants clinical assessment of modifiable risk factors and baseline renal function

Lifestyle

  • Weight management if overweight Moderate

    Obesity increases CKD risk and progression; weight loss improves renal outcomes

    Maintain BMI 18.5-24.9; pursue gradual weight loss if BMI above 25

Screening

  • Blood pressure Moderate

    Hypertension accelerates CKD in genetically predisposed individuals

    Home BP monitoring monthly or clinical checks quarterly

  • Kidney function with annual urinalysis and eGFR Moderate

    GWAS identifies genetic predisposition to chronic kidney disease (p=6e-6, n=117k)

    Annual eGFR, serum creatinine, and urinalysis; begin immediately