rs1031782 - RPL13AP25 - LINC02335
Magnitude 2.8 · 1 study on file
Reported associations
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Multi-trait genome-wide association study of opioid addiction: OPRM1 and beyond - Unknown journal (n.d.) · Unknown authors · PubMed 36207451
ABSTRACT: Opioid addiction (OA) is moderately heritable, yet only rs1799971, the A118G variant in OPRM1, has been identified as a genome-wide significant association with OA and independently replicated. We applied genomic structural equation modeling to conduct a GWAS of the new Genetics of Opioid Addiction Consortium (GENOA) data together with published studies (Psychiatric Genomics Consortium, Million Veteran Program, and Partners Health), comprising 23,367 cases and effective sample size of 88,114 individuals of European ancestry. Genetic correlations among the various OA phenotypes were uniformly high (rg > 0.9). We observed the strongest evidence to date for OPRM1: lead SNP rs9478500 (p = 2.56 × 10-9). Gene-based analyses identified novel genome-wide significant associ
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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opioid addiction genetic risk when planning pain management Moderate
Variant rs1031782 confers increased opioid addiction risk
Inform your healthcare provider of this genetic finding before opioids are prescribed
Lifestyle
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unnecessary opioid exposure given addiction genetic risk Moderate
Variant rs1031782 confers elevated genetic predisposition to opioid addiction
Request non-opioid pain management options when medically feasible; discuss alternatives with your doctor