rs1031755 - WDR72
Magnitude 2.8 · 1 study on file
Reported associations
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Trans-ethnic Fine Mapping Highlights Kidney-Function Genes Linked to Salt Sensitivity - Unknown journal (n.d.) · Unknown authors · PubMed 27588450
ABSTRACT: We analyzed genome-wide association studies (GWASs), including data from 71,638 individuals from four ancestries, for estimated glomerular filtration rate (eGFR), a measure of kidney function used to define chronic kidney disease (CKD). We identified 20 loci attaining genome-wide-significant evidence of association (p < 5 × 10−8) with kidney function and highlighted that allelic effects on eGFR at lead SNPs are homogeneous across ancestries. We leveraged differences in the pattern of linkage disequilibrium between diverse populations to fine-map the 20 loci through construction of "credible sets" of variants driving eGFR association signals. Credible variants at the 20 eGFR loci were enriched for DNase I hypersensitivity sites (DHSs) in human kidney cells. DHS credible va
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Diet
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Moderate sodium intake Moderate
Salt sensitivity impairs kidney glomerular filtration through mechanisms relevant to kidney function genetic variants; sodium restriction may preserve kidney function
Target sodium below 2300mg daily; reduce further if hypertension or kidney disease develops
Discuss with your doctor
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Personalized kidney health monitoring plan Moderate
Carriers of the WDR72 A allele have genetically reduced kidney function; individualized screening and risk reduction strategies are clinically appropriate
Discuss with primary care or nephrologist to establish baseline kidney function and monitoring frequency
Screening
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Kidney function and glomerular filtration rate High
The WDR72 A allele is associated with reduced glomerular filtration rate, a key marker of kidney function and chronic kidney disease risk
Annual eGFR and serum creatinine; more frequent if additional kidney disease risk factors