rs1030766 - LCT
Magnitude 2.2 · 1 study on file
Reported associations
-
Genomic atlas of the human plasma proteome - Unknown journal (n.d.) · Unknown authors · PubMed 29875488
ABSTRACT: Although plasma proteins have important roles in biological processes and are the direct targets of many drugs, the genetic factors that control inter-individual variation in plasma protein levels are not well understood. Here we characterize the genetic architecture of the human plasma proteome in healthy blood donors from the INTERVAL study. We identify 1,927 genetic associations with 1,478 proteins, a fourfold increase on existing knowledge, including trans associations for 1,104 proteins. To understand the consequences of perturbations in plasma protein levels, we apply an integrated approach that links genetic variation with biological pathway, disease, and drug databases. We show that protein quantitative trait loci overlap with gene expression quantitative trait loci, as w
Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.
Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Diet
-
dairy intake based on individual tolerance Moderate
rs1030766 genotype determines lactase-phlorizin hydrolase levels, affecting lactose digestion capacity
assess personal tolerance; reduce high-lactose products if experiencing bloating, cramping, or digestive symptoms
Supplements
-
lactase enzyme supplement Moderate
Exogenous lactase compensates for genetically determined lower enzyme production from LCT C allele
use before consuming dairy if intolerant; available over-the-counter as pills or liquid