rs10305494 - GLP1R
Magnitude 4.5 · 1 study on file
Reported associations
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New role of fat-free mass in cancer risk linked with genetic predisposition. - Scientific reports (2024) · Harris BHL, Di Giovannantonio M, Zhang P, Harris DA, Lord SR, Allen NE, Maughan TS, Bryant RJ, Harris AL, Bond GL, Buffa FM · PubMed 38538606
Cancer risk is associated with the widely debated measure body mass index (BMI). Fat mass and fat-free mass measurements from bioelectrical impedance may further clarify this association. The UK Biobank is a rare resource in which bioelectrical impedance and BMI data was collected on ~ 500,000 individuals. Using this dataset, a comprehensive analysis using regression, principal component and genome-wide genetic association, provided multiple levels of evidence that increasing whole body fat (WBFM) and fat-free mass (WBFFM) are both associated with increased post-menopausal breast cancer risk, and colorectal cancer risk in men. WBFM was inversely associated with prostate cancer. We also identified rs615029[T] and rs1485995[G] as associated in independent analyses with both PMBC (p =
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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Colorectal cancer risk and prevention strategy Moderate
Genetic variant increases baseline colorectal cancer risk, warranting physician discussion of screening timing and lifestyle measures
Discuss with gastroenterologist or primary care physician
Screening
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Colorectal cancer screening starting at age 40 Moderate
GLP1R rs10305494 T allele shows 1.96-fold increased colorectal cancer risk in large GWAS cohort
Begin screening at age 40 instead of standard age 45; discuss schedule with physician