rs1029296 - PPP1R2P1 - HLA-Z

Magnitude 2.2 · 1 study on file

Reported associations

• Novel genetic variants associated with lumbar disc degeneration in northern Europeans: a meta-analysis of 4600 subjects - Unknown journal (n.d.) · Unknown authors · PubMed 22993228

  ABSTRACT: Objective Lumbar disc degeneration (LDD) is an important cause of low back pain, which is a common and costly problem. LDD is characterised by disc space narrowing and osteophyte growth at the circumference of the disc. To date, the agnostic search of the genome by genome-wide association (GWA) to identify common variants associated with LDD has not been fruitful. This study is the first GWA meta-analysis of LDD. Methods We have developed a continuous trait based on disc space narrowing and osteophytes growth which is measurable on all forms of imaging (plain radiograph, CT scan and MRI) and performed a meta-analysis of five cohorts of Northern European extraction each having GWA data imputed to HapMap V.2. Results This study of 4600 individuals identified four single nucleotide

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