rs10283388 - RGS22
Magnitude 2.2 · 1 study on file
Reported associations
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Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program - Unknown journal (n.d.) · Unknown authors · PubMed 39024449
ABSTRACT: INTRODUCTION: Findings from genome-wide association studies (GWASs) have provided foundational knowledge of the genetic basis of disease, facilitating precision approaches for prevention and treatment. Current GWAS results are limited by underrepresentation of individuals from diverse populations, leading to concerns with generalizability regarding our knowledge of the relationships between genes, traits, and disease. The Department of Veterans Affairs (VA) Million Veteran Program (MVP), one of the largest US-based biobanks, addresses this need; 29% of MVP comprises individuals genetically similar to African (AFR), Admixed American (AMR), and East Asian (EAS) reference populations. With over 635,000 participants and more than 44.3M genotyped variants linked with detailed phenotyp
Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.
Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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Genetic skin cancer risk with dermatologist High
rs10283388 T-allele is associated with substantially increased non-epithelial skin cancer risk; professional surveillance can optimize early detection
Discuss rs10283388 GWAS finding at dermatology appointment; confirm appropriate screening frequency
Lifestyle
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Daily broad-spectrum sun protection High
Increased genetic predisposition to non-epithelial skin cancer makes UV protection a more critical modifiable risk factor
SPF 30+ daily sunscreen; protective clothing; limit peak sun exposure (10am-4pm)