rs10282989: variant overview & research summary

Magnitude 2.8 · 1 study on file

Genome-wide association study of germline variants and breast cancer-specific mortality - Unknown journal (n.d.) · Unknown authors · PubMed 30787463

ABSTRACT: Background We examined the associations between germline variants and breast cancer mortality using a large meta-analysis of women of European ancestry. Methods Meta-analyses included summary estimates based on Cox models of twelve datasets using ~10.4 million variants for 96,661 women with breast cancer and 7697 events (breast cancer-specific deaths). Oestrogen receptor (ER)-specific analyses were based on 64,171 ER-positive (4116) and 16,172 ER-negative (2125) patients. We evaluated the probability of a signal to be a true positive using the Bayesian false discovery probability (BFDP). Results We did not find any variant associated with breast cancer-specific mortality at P < 5 × 10−8. For ER-positive disease, the most significantly associated variant was chr7:rs4717

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rs10282989 - SAMD12