rs1028166 - TENM3-AS1

Magnitude 2.8 · 1 study on file

Reported associations

• No evidence of gene-calcium interactions from genome-wide analysis of colorectal cancer risk - Unknown journal (n.d.) · Unknown authors · PubMed 25192705

  ABSTRACT: Background Calcium intake may reduce risk of colorectal cancer (CRC), but the mechanisms remain unclear. Studies of interaction between calcium intake and single nucleotide polymorphisms (SNPs) in calcium-related pathways have yielded inconsistent results. Methods To identify gene-calcium interactions, we tested interactions between ~2.7 million SNPs across the genome with self-reported calcium intake (from dietary or supplemental sources) in 9,006 CRC cases and 9,503 controls of European ancestry. To test for multiplicative interactions, we used multivariable logistic regression and defined statistical significance using the conventional genome-wide α=5E-08. Results After accounting for multiple comparisons, there were no statistically significant SNP-interactions with total, d

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