rs1027896 - ADGRG6 - HIVEP2
Magnitude 4.5 · 1 study on file
Reported associations
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Genetic Variants in the Bone Morphogenic Protein Gene Family Modify the Association between Residential Exposure to Traffic and Peripheral Arterial Disease - Unknown journal (n.d.) · Unknown authors · PubMed 27082954
ABSTRACT: There is a growing literature indicating that genetic variants modify many of the associations between environmental exposures and clinical outcomes, potentially by increasing susceptibility to these exposures. However, genome-scale investigations of these interactions have been rarely performed particularly in the case of air pollution exposures. We performed race-stratified genome-wide gene-environment interaction association studies on European-American (EA, N = 1623) and African-American (AA, N = 554) cohorts to investigate the joint influence of common single nucleotide polymorphisms (SNPs) and residential exposure to traffic ("traffic exposure")-a recognized vascular disease risk factor-on peripheral arterial disease (PAD). Traffic exposure was estimated via the dis
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Lifestyle
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high levels of traffic-related air pollution Moderate
The variant demonstrates significant interaction with air pollution in increasing PAD risk; minimizing exposure may reduce genetic risk expression.
Monitor local air quality index; plan exercise and outdoor activities to avoid high-pollution days.
Screening
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peripheral arterial disease screening Moderate
Genetic variant rs1027896 is associated with increased peripheral arterial disease risk, particularly with air pollution exposure.
Discuss with cardiologist whether baseline PAD screening is warranted given genetic predisposition.