rs10278336 - YKT6

Magnitude 2.2 · 1 study on file

Reported associations

• Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes - Unknown journal (n.d.) · Unknown authors · PubMed 22885922

  ABSTRACT: To extend understanding of the genetic architecture and molecular basis of type 2 diabetes (T2D), we conducted a meta-analysis of genetic variants on the Metabochip involving 34,840 cases and 114,981 controls, overwhelmingly of European descent. We identified ten previously unreported T2D susceptibility loci, including two demonstrating sex-differentiated association. Genome-wide analyses of these data are consistent with a long tail of further common variant loci explaining much of the variation in susceptibility to T2D. Exploration of the enlarged set of susceptibility loci implicates several processes, including CREBBP-related transcription, adipocytokine signalling and cell cycle regulation, in diabetes pathogenesis. FULL TEXT: [INTRO] Type 2 diabetes (T2D) is a chronic meta

Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.