rs1027643 - PCBP2P3 - LDHBP3

Magnitude 2.8 · 1 study on file

Reported associations

• A genome-wide association study identifies susceptibility loci for Wilms tumor - Unknown journal (n.d.) · Unknown authors · PubMed 22544364

  ABSTRACT: Wilms tumor is the most common renal malignancy of childhood. To identify common variants that confer susceptibility to Wilms tumor we conducted a genome-wide association study in 757 cases and 1,879 controls. We evaluated ten SNPs in regions significant at P<5×10−5 in two independent replication series from the UK (769 cases and 2,814 controls) and the US (719 cases and 1,037 controls). We identified clear significant associations at two loci, 2p24 (rs3755132, P=1.03×10−14 and rs807624, P=1.32×10−14) and 11q14 (rs790356, P=4.25 ×10−15). Both regions contain genes that are plausibly related to Wilms tumorigenesis. We also identified candidate signals at 5q14, 22q12 and Xp22. FULL TEXT: [INTRO] Wilms tumor is a childhood embryonal kidney cancer that affects approximat

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