rs10276423 - UMAD1

Magnitude 2.2 · 1 study on file

Reported associations

• Multi‐ancestry meta‐analysis identifies genetic modifiers of age‐at‐onset of Alzheimer's disease at known and novel loci - Unknown journal (n.d.) · Unknown authors · PubMed 40883957

  ABSTRACT: Abstract INTRODUCTION Much of Alzheimer's disease (AD) risk is explained by age, apolipoprotein E (APOE) genotype, and sex. We sought to identify genetic modifiers of age at onset (AAO) of AD while probing the influence of sex and APOE among those with diverse ancestry. METHODS We performed genome‐wide association studies (GWASs) of AAO in two diverse samples followed by meta‐analysis, contrasting results with and without adjustment for sex and APOE. Genome‐wide significance was set to p < 5×10−8. RESULTS GWASs adjusting for sex, APOE, population structure, and relatedness revealed 17 significant loci including independent associations at AD risk loci and four novel signals. APOE adjustment influenced GWAS effect sizes across the genome while sex adjustment had minimal

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